| Pair Name | AKBA, Cisplatin | ||
| Phytochemical Name | AKBA (PubChem CID: 11168203 ) | ||
| Anticancer drug Name | Cisplatin (PubChem CID: 5702198 ) | ||
| Structure of Phytochemical |
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MOL
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| Structure of Anticancer Drug |
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| Pair Name | AKBA, Cisplatin | |||
| Disease Info | [ICD-11: 2C25] | Lung cancer | Investigative | |
| Biological Phenomena | Induction-->Blockade of cell cycle in G0/G1 phase | |||
| Gene Regulation | Down-regulation | Expression | ATG5 | hsa9474 |
| Down-regulation | Expression | BCL-xL | hsa598 | |
| Down-regulation | Expression | CCNA2 | hsa890 | |
| Down-regulation | Expression | CCNE1 | hsa898 | |
| Down-regulation | Phosphorylation | CDK1 | hsa983 | |
| Down-regulation | Expression | CDK4 | hsa1019 | |
| Up-regulation | Expression | CDKN1A | hsa1026 | |
| Down-regulation | Expression | MAP1LC3A | hsa84557 | |
| Down-regulation | Expression | MAP1LC3B | hsa81631 | |
| Up-regulation | Expression | PSMD9 | hsa5715 | |
| In Vitro Model | A-549 | Lung adenocarcinoma | Homo sapiens (Human) | CVCL_0023 |
| Result | Acetyl-11-keto-beta-boswellic acid enhances the cisplatin sensitivity of non-small cell lung cancer cells through cell cycle arrest, apoptosis induction, and autophagy suppression via p21-dependent signaling pathway | |||
| No. | Title | Href |
|---|---|---|
| 1 | Acetyl-11-keto-β-boswellic acid enhances the cisplatin sensitivity of non-small cell lung cancer cells through cell cycle arrest, apoptosis induction, and autophagy suppression via p21-dependent signaling pathway. Cell Biol Toxicol. 2021 Apr;37(2):209-228. doi: 10.1007/s10565-020-09541-5. | Click |
